> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PTPN11 Antibody (ascites)Brand |
Leading Biology | Catalog Number |
APR13021G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PTPN11 antibody (ascites).
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Molecular Weight |
68436 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm.
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Host |
Mouse
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Species Reactivity |
Mouse
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Target |
This PTPN11 monoclonal antibody is generated from mouse immunized with PTPN11 recombinant protein.
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Clone |
246CT9.8.2
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Isotype |
IgG1,k
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Symbol |
PTP2C, SHPTP2
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GeneID |
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UniProt ID |
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Function |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
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Summary |
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains two tandem Srchomology-2 domains, which function as phospho-tyrosine bindingdomains and mediate the interaction of this PTP with itssubstrates. This PTP is widely expressed in most tissues and playsa regulatory role in various cell signaling events that areimportant for a diversity of cell functions, such as mitogenicactivation, metabolic control, transcription regulation, and cellmigration. Mutations in this gene are a cause of Noonan syndrome aswell as acute myeloid leukemia.
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~500
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Synonyms |
Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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