> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > RYK AntibodyBrand |
Leading Biology | Catalog Number |
AMM07704G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RYK antibody.
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Molecular Weight |
67507 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
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Host |
Mouse
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Species Reactivity |
Human
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Target |
This RYK monoclonal antibody is generated from mouse immunized with RYK recombinant protein.
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Clone |
240CT2.2.4
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Isotype |
IgG2b,k
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Symbol |
JTK5A
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GeneID |
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UniProt ID |
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Function |
May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
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Summary |
The protein encoded by this gene is an atypical member ofthe family of growth factor receptor protein tyrosine kinases,differing from other members at a number of conserved residues inthe activation and nucleotide binding domains. This gene productbelongs to a subfamily whose members do not appear to be regulatedby phosphorylation in the activation segment. It has been suggestedthat mediation of biological activity by recruitment of asignaling-competent auxiliary protein may occur through an as yetuncharacterized mechanism. Two alternative splice variants havebeen identified, encoding distinct isoforms.
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~500
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Synonyms |
Tyrosine-protein kinase RYK, RYK, JTK5A
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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