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MMP14 Antibody (C-term) (Ascites)

APR08463G Product Datasheet Protocol

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APR08463G		0.1 ml / $495

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Leading Biology Inc.

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MMP14 Antibody (C-term) (Ascites)

Brand	Leading Biology	Catalog Number	APR08463G
Product Type	Monoclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MMP14 antibody (C-term) (Ascites).
Molecular Weight	65894 Da
Cellular Localization	Antigen Cellular Localization: Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm
Host	Mouse
Species Reactivity	Human
Immunogen	470-499 aa
Target	This MMP14 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP14.
Clone	133CT15.10.5.1
Isotype	IgM
GeneID	4323
UniProt ID	P50281
Function	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
Summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Form	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, FC, E
Dilution	WB~~1:1000~16000 IHC-P~~1:50~100 FC~~1:10~50
Synonyms	Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14
Images	Western blot analysis of MMP14 Antibody (C-term) (Cat. APR08463G) in A2058 cell line lysates (35μg/lane).MMP14 (arrow) was detected using the purified Mab.(1:1000) MMP14 Antibody (C-term)(Ascites) (Cat. APR08463G) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjμgation of the secondary antibody and DAB staining. This data demonstrates the use of the MMP14 Antibody (C-term)(Ascites) for immunohistochemistry. Clinical relevance has not been evaluated. MMP14 Antibody (C-term)(Ascites) (Cat. APR08463G) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-mouse secondary antibodies were used for the analysis.
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