> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Thymidylate Synthase (5-FU Resistance Marker) Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
APG01289G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Thymidylate Synthase (5-FU Resistance Marker) antibody - With BSA and Azide.
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Molecular Weight |
36kDa
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Recombinant human thymidylate synthase
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Clone |
TMS715
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Isotype |
IgG1, kappa
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Symbol |
TS
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GeneID |
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UniProt ID |
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Function |
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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Summary |
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
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Form |
0.5 ml at 200ug/ml with BSA and azide |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, FC, IP, E
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Synonyms |
Thymidylate synthase, TS, TSase, TYMS, TS
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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