> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > ATG4D AntibodyBrand |
Leading Biology | Catalog Number |
APR10859G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ATG4D antibody.
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Molecular Weight |
52922 Da
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Cellular Localization |
Antigen Cellular Localization:
Cysteine protease ATG4D: Cytoplasm.
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Host |
Mouse
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Species Reactivity |
Human
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Target |
This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.
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Clone |
222CT15.4.1
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Isotype |
IgG1,K
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Symbol |
APG4D, AUTL4
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GeneID |
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UniProt ID |
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Function |
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
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Summary |
Autophagy is the process by which endogenous proteins anddamaged organelles are destroyed intracellularly. Autophagy ispostulated to be essential for cell homeostasis and cell remodelingduring differentiation, metamorphosis, non-apoptotic cell death,and aging. Reduced levels of autophagy have been described in somemalignant tumors, and a role for autophagy in controlling theunregulated cell growth linked to cancer has been proposed. Thisgene encodes a member of the autophagin protein family. The encodedprotein is also designated as a member of the C-54 family ofcysteine proteases.
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF, E
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Dilution |
IF~~1:25
WB~~1:100~1000
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Synonyms |
Cysteine protease ATG4D, 3422-, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, Cysteine protease ATG4D, mitochondrial, ATG4D, APG4D, AUTL4
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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