> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > TFF1 AntibodyBrand |
Leading Biology | Catalog Number |
AMM08170G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TFF1 antibody.
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Molecular Weight |
9150 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues in human TFF1 was used as an immunogen.
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Clone |
EPR3972
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Symbol |
BCEI, PS2
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GeneID |
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UniProt ID |
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Function |
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.
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Summary |
Trefoil factor 1 (TFF1), a member of the trefoil factor family, is a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents (1). It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability (2). TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract (3). It is specifically found in the stomach, with highest expression levels in the upper gastric mucosal cells (1). TFF1 is most strongly expressed in pancreas, large bowel, and breast cancer (1). In breast cancer, its regulation by estrogen is an indicator of estrogen receptor (ER) functionality (4).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:1000~10000
IHC~~1:100~250
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Synonyms |
Trefoil factor 1, Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1A, hP1A, Protein pS2, TFF1, BCEI, PS2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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