> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > TCF-3 AntibodyBrand |
Leading Biology | Catalog Number |
AMM08126G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TCF-3 antibody.
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Molecular Weight |
62631 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.
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Clone |
EPR2031
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Symbol |
TCF3
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GeneID |
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UniProt ID |
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Function |
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
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Summary |
T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:1000~5000
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Synonyms |
Transcription factor 7-like 1, HMG box transcription factor 3, TCF-3, TCF7L1, TCF3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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