> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Phospholamban Antibody Phospho (pS16)Brand |
Leading Biology | Catalog Number |
APR09271G |
Product Type |
Monoclonal Antibodies | Field of Research |
|
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospholamban antibody Phospho (pS16).
|
||
Molecular Weight |
6109 Da
|
||
Cellular Localization |
Antigen Cellular Localization:
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
|
||
Host |
Rabbit
|
||
Species Reactivity |
Human, Mouse
|
||
Target |
A phospho specific peptide corresponding to residues surrounding Serine 16 of human Phospholamban was used as an immunogen.
|
||
Clone |
EPR1911
|
||
Symbol |
PLB
|
||
GeneID |
|||
UniProt ID |
|||
Function |
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
|
||
Summary |
Phospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1).
|
||
Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
||
Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
Applications |
WB
|
||
Dilution |
WB~~1:200000~500000
|
||
Synonyms |
Cardiac phospholamban, PLB, PLN, PLB
|
||
Images |
|
||
Specification |
|||
Quantity |
|
||
| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | APG02467G | CCK4 / PTK7 Antibody (clone 4F9) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask | ||
| 2 | Leading Biology | AMM04683G | GALT Antibody (clone 4C11) | 50 μg | Monoclonal Antibodies |
|
$545.00 | Add Ask | ||
| 3 | Leading Biology | AMM01402G | Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
| 4 | Leading Biology | APR08280G | LTA4H / LTA4 Antibody (clone 9G8) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask | ||
| 5 | Leading Biology | AMM00172G | CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
| 6 | Leading Biology | AMM05750G | CEBPA Antibody | 100 μl | Monoclonal Antibodies |
|
$545.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
You have 0 item in your cart
You have 0 item in your inquiry list
