> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PAX2 AntibodyBrand |
Leading Biology | Catalog Number |
APR12726G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAX2 antibody.
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Molecular Weight |
44706 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
A synthetic peptide corresponding to residues in human PAX2 was used as an immunogen.
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Clone |
EP3251
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GeneID |
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UniProt ID |
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Function |
Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
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Summary |
PAX2 is a transcription factor that plays a key role during renal development and angiogenesis and through the Akt-survival pathway (1). PAX2 is also expressed in normal renal medulla where it is regulated by the normally high and variable NaCl concentration, and it protects renal medullary cells from high NaCl concentration-induced apoptosis (2). Recent reports show that PAX2 also plays a role in breast cancer by competing with the ER co-activator AIB-1/SRC-3 for the binding and regulation of ERBB2 transcription (3). PAX2 is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system (4).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:1000~10000
IHC~~1:1000~2500
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Synonyms |
Paired box protein Pax-2, PAX2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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