> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Op18 Antibody Phospho (pS24)Brand |
Leading Biology | Catalog Number |
AMM06905G |
Product Type |
Monoclonal Antibodies | Field of Research |
|
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Op18 antibody Phospho (pS24).
|
||
Molecular Weight |
17303 Da
|
||
Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton.
|
||
Host |
Rabbit
|
||
Species Reactivity |
Human, Mouse, Rat
|
||
Target |
A phospho specific peptide corresponding to residues surrounding Serine 24 of human Op18 was used as an immunogen. This antibody detects Op18 phosphorylated at Serine 24.
|
||
Clone |
EP2124Y
|
||
Symbol |
C1orf215, LAP18, OP18
|
||
GeneID |
|||
UniProt ID |
|||
Function |
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
|
||
Summary |
Oncoprotein 18 (Op18) is a proliferation-related cytosolic phosphoprotein which is induced in normal lymphocytes following mitogenic stimulation. Studies of Op18 are of particular interest because of the proposed role it plays in signal transduction and because of its occurrence in markedly increased amounts in acute leukemia cells (1). Oncoprotein 18 has been independently identified due to its increased phosphorylation in response to external signals and its up-regulated expression in acute leukemia. Findings suggest that Op18 may be a physiological substrate for several members of the cdc2 kinase family during both the S-phase and the mitotic phase of the cell cycle (2). Also, findings show that Op18 by itself can fold into a flexible and extended alpha-helix, which is in equilibrium with a less ordered structure. In complex with tubulin, however, all except the last seven C-terminal residues of Op18 are tightly bound to tubulin. Studies suggest results suggest that besides sequestering tubulin, the structural features of Op18 enable the protein specifically to recognize microtubule ends to trigger catastrophes (3).
|
||
Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
||
Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
Applications |
WB
|
||
Dilution |
WB~~1:500~1000
|
||
Synonyms |
Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18
|
||
Images |
|
||
Specification |
|||
Quantity |
|
||
| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | APG02467G | CCK4 / PTK7 Antibody (clone 4F9) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask | ||
| 2 | Leading Biology | AMM04683G | GALT Antibody (clone 4C11) | 50 μg | Monoclonal Antibodies |
|
$545.00 | Add Ask | ||
| 3 | Leading Biology | AMM01402G | Vimentin (Mesenchymal Cell Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
| 4 | Leading Biology | APR08280G | LTA4H / LTA4 Antibody (clone 9G8) | 50 μl | Monoclonal Antibodies |
|
$495.00 | Add Ask | ||
| 5 | Leading Biology | AMM00172G | CD1a / HTA1 (Mature Langerhans Cells Marker) Antibody - With BSA and Azide | 50 ug | Monoclonal Antibodies |
|
$395.00 | Add Ask | ||
| 6 | Leading Biology | AMM05750G | CEBPA Antibody | 100 μl | Monoclonal Antibodies |
|
$545.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
You have 0 item in your cart
You have 0 item in your inquiry list
