> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > NMDAR1 Antibody Phospho (pS889)Brand |
Leading Biology | Catalog Number |
AMM06721G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NMDAR1 antibody Phospho (pS889).
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Molecular Weight |
105373 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A phospho specific peptide corresponding to residues surrounding serine 889 of human NMDAR1 was used as an immunogen. This antibody detects NMDAR1 phosphorylated at serine 889.
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Clone |
EPR2480Y
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Symbol |
NMDAR1
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GeneID |
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UniProt ID |
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Function |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
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Summary |
The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. Molecular cloning has demonstrated that NMDA receptors consist of several homologous subunits (NMDAR1). A variety of studies have suggested that protein phosphorylation of NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation. PKC phosphorylation occurs on several distinct sites on the NR1 subunit. Most of these sites are contained within a single alternatively spliced exon in the C-terminal domain, which has previously been proposed to be on the extracellular side of the membrane (1). A role for NMDAR1 in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of neurochemical studies in HD and the ability of the NMDAR1 to mediate neuronal cell death (2). Also, studies reveal a unrecognized role of the NMDAR1 in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:2000~5000
IHC~~1:100~250
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Synonyms |
Glutamate receptor ionotropic, NMDA 1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, GRIN1, NMDAR1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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