> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > EYA2 AntibodyBrand |
Leading Biology | Catalog Number |
APR11883G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EYA2 antibody.
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Molecular Weight |
59232 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues near the N-terminus region of human EYA2 was used as an immunogen.
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Clone |
EPR2942
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Symbol |
EAB1
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GeneID |
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UniProt ID |
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Function |
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
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Summary |
EYA2 (eyes absent homolog 2) is a human homologue of the Drosophila Eya transcription co-activator. EYA2 is a cytosolic tyrosine phosphatase which translocates to the nucleaus by the Six homeodomain-containing family of proteins, where it becomes cofactor for the transcription factor SIX1. Specifically, EYA2 dephosphorylates tyrosine 142 of histone H2AX and, therefore, it is thought to be involved in transcription regulation during organogenesis. Also, together with SIX1 and DACH2, EYA2 seems to be involved in myogensis. EYA2 translocation and transcriptional activity are inhibited by its direct interaction with activated GNAZ and GNAI2. EYA2 might be involved in the development of eye (1, 2).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:1000~10000
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Synonyms |
Eyes absent homolog 2, EYA2, EAB1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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