> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > ER beta AntibodyBrand |
Leading Biology | Catalog Number |
AMM04427G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ER beta antibody.
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Molecular Weight |
59216 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:19126643}
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to N-terminus of human ER beta was used as an immunogen.
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Clone |
EPR3777
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Symbol |
ESTRB, NR3A2
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GeneID |
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UniProt ID |
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Function |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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Summary |
Estrogen Receptor beta (ER beta) is a nuclear hormone receptor which is highly homologous to ER alpha. It functions as a ligand-activated transcription factor, binding to estrogens and activation expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (1). Studies have shown ER beta play a role in modulation of the effects of ER alpha, possibly by inhibiting the transcription activation of ER alpha (2). ER beta is expressed in many tissues, including human thymus, spleen, ovary and testis. It is also highly expressed in endothelial and vascular smooth muscles cells, and the expression of ER beta in these areas has a positive correlation with increased coronary artery plaque (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF
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Dilution |
WB~~1:50000~200000
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Synonyms |
Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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