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CCR7/CKR7 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR15289G 100 μl / $545

CCR7/CKR7 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR15289G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CCR7/CKR7 antibody (N-term).

Molecular Weight

42874 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

A synthetic peptide corresponding to residues in N-terminal extracellular domain of human CKR7 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.

Clone

Y59

Symbol

CMKBR7, EBI1, EVI1

GeneID

UniProt ID

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Summary

CKR7, or C-C chemokine receptor type 7, is a G protein-coupled, seven-transmembrane domain receptor protein. Originally identified as the EBV-induced gene-1 (1), CKR7 was later found to be the receptor for the chemokines CCL21 (SLC, 6Ckine, Exodus-2) (3) and CCL19 (MIP-3 beta, Exodus-3, ELC) (4). CCR7 is expressed in lymphoid tissues and activated B and T lymphocytes (2). It is up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7 (4).

Form

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, IF

Dilution

WB~~1:10000 IHC~~1:250

Synonyms

C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, EBI1, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, CCR7, CMKBR7, EBI1, EVI1

Images

A. Western blot analysis on (left) K562 and (right) Daudi cell lysates using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G), dilution 1:5,000.

B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G).

C. Immunofluorescent staining of HeLa cells using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G).

Specification

Quantity

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