> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CCR7/CKR7 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR15289G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CCR7/CKR7 antibody (N-term).
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Molecular Weight |
42874 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in N-terminal extracellular domain of human CKR7 was used as immunogen. The antibody does not cross-react with other G-protein coupled receptor 1 family members.
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Clone |
Y59
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Symbol |
CMKBR7, EBI1, EVI1
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GeneID |
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UniProt ID |
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Function |
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
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Summary |
CKR7, or C-C chemokine receptor type 7, is a G protein-coupled, seven-transmembrane domain receptor protein. Originally identified as the EBV-induced gene-1 (1), CKR7 was later found to be the receptor for the chemokines CCL21 (SLC, 6Ckine, Exodus-2) (3) and CCL19 (MIP-3 beta, Exodus-3, ELC) (4). CCR7 is expressed in lymphoid tissues and activated B and T lymphocytes (2). It is up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7 (4).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF
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Dilution |
WB~~1:10000
IHC~~1:250
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Synonyms |
C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, EBI1, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, CCR7, CMKBR7, EBI1, EVI1
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Images |
A. Western blot analysis on (left) K562 and (right) Daudi cell lysates using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G), dilution 1:5,000.
B. Immunohistochemical analysis of paraffin-embedded human spleen using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G).
C. Immunofluorescent staining of HeLa cells using anti-CKR7/CCR7 (N-term) RabMAb (Cat. APR15289G). |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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