> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > AMACR AntibodyBrand |
Leading Biology | Catalog Number |
APG01834G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AMACR antibody.
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Molecular Weight |
42387 Da
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Cellular Localization |
Antigen Cellular Localization:
Peroxisome. Mitochondrion
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in human AMACR was used as an immunogen.
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Clone |
EPR3717
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GeneID |
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UniProt ID |
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Function |
Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
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Summary |
Alpha-methylacyl-CoA racemase (AMACR) primary role involves the racemization of 2-methyl-branched fatty acid CoA esters and the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers (1). A central role in all the metabolic pathways is played by AMACR, which regulates metabolism of lipids. AMACR regulates the entry of branched-chain lipids into the peroxisomal and mitochondrial beta-oxidation pathways (2). It has also been proven to be one of the few biomarkers that can help distinguish cancer from benign cells, with high sensitivity and specificity for prostate carcinoma (3). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) that results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa and epilepsy (1).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Dilution |
WB~~1:1000~5000
IHC~~1:100~250
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Synonyms |
Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACR
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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