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P16 (Mouse and Human) Antibody

AMM02637G Product Datasheet Protocol

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AMM02637G		100 μl / $545

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Leading Biology Inc.

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P16 (Mouse and Human) Antibody

Brand	Leading Biology	Catalog Number	AMM02637G
Product Type	Monoclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality P16 (Mouse and Human) Antibody.
Molecular Weight	16533 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm. Nucleus
Host	Mouse
Species Reactivity	Human, Mouse, Rat
Clone	1E12E10
Isotype	IgG1
Symbol	CDKN2, MTS1
GeneID	1029
UniProt ID	P42771
Function	Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC, E
Dilution	WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000
Images	Figure 1: Western blot analysis using P16 mouse mAb against truncated P16 recombinant protein. Figure 2: Immunohistochemical analysis of paraffin-embedded rat liver tissue (A), human brain tumor (B), breast cancer (C), esophageal epithelium tissue (D), mouse brain tissue (E) and stomach tisue (F), showing nuclear localization using P16 mouse mAb with DAB staining.
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