> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Phospho-Ser190 Progesterone Receptor AntibodyBrand |
Leading Biology | Catalog Number |
AMM02580G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser190 Progesterone Receptor Antibody.
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Molecular Weight |
90/120 KDa
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Host |
mouse
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Species Reactivity |
Human
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Target |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser190 conjugated to KLH.
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Clone |
1154
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Isotype |
IgG1
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GeneID |
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UniProt ID |
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Summary |
There is accumulating evidence to suggest that progesteroneplaysan essential role in the regulation of growth and differentiationof mammary glands and thus mayplay a key role in breast cancer (Edwards, 2005). The biological response to progesterone ismediated by two distinct formsof the human progesterone receptor (PR-A and PR-B forms). Inmost cellcontexts, the B form functions as a transcriptional activator, whereas the A formfunctions as a transcriptionalinhibitor of steroid hormones (Attia et al., 2000; Lin et al., 2003).Recently it has been demonstrated that there is differential hormone dependent regulation of thephosphorylation of the A and B forms of the receptor (Clemm et al., 2000) . Treatment of T47Dbreast cancer cells with progestin agonist increases the phosphorylation of Ser190and Ser294with different kinetics. These phosphorylation events may differentially affect the transcriptionalactivity of the receptor.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~ 1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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