> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > AIM2 AntibodyBrand |
Leading Biology | Catalog Number |
AMM03078G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AIM2 Antibody.
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Molecular Weight |
39kDa
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles
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Host |
Mouse
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Species Reactivity |
Human
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Clone |
7G12D1
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Isotype |
IgG1
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GeneID |
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UniProt ID |
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Function |
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, FC, ICC, E
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Dilution |
E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | AMM05750G | CEBPA Antibody | 100 μl | Monoclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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