> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > NEDD8 Antibody (clone 5B8)Brand |
Leading Biology | Catalog Number |
AMM02245G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NEDD8 Antibody (clone 5B8).
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Molecular Weight |
9kDa
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Note=Mainly nuclear
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Human NEDD8
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Clone |
5B8
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GeneID |
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UniProt ID |
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Function |
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
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Summary |
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, ICC, E, Flo
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Dilution |
ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IF (1:1000), IHC-P (10 μg/ml), WB (1:500-1:2000),
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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