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FMR1 Antibody

Catalog # Availability Size / Price Inquiry
AMM02709G 100 μl / $495

FMR1 Antibody

Brand

Leading Biology

Catalog Number

AMM02709G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FMR1 Antibody.

Molecular Weight

71kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus, nucleolus.

Host

Mouse

Species Reactivity

Human

Clone

4G9

Isotype

IgG1

GeneID

UniProt ID

Function

Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, ICC, E

Dilution

WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000 IF~~1/200 - 1/1000 ICC~~1:200~~1000

Images

Figure 1: Western blot analysis using FMR1 mouse mAb against Jurkat (1) and K562 (2) cell lysate.

Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissues, showing cytoplasmic localization with DAB staining using FMR1 mouse mAb.

Figure 3: Immunofluorescence analysis of NIH/3T3 cells using FMR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Specification

Quantity

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