> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > TRIM29 (Lung Squamous Cell Carcinoma Marker) AntibodyBrand |
Leading Biology | Catalog Number |
AMM00699G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody.
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Molecular Weight |
66kDa
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Note=Colocalizes with intermediate filaments
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Host |
Mouse
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Species Reactivity |
Human
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Clone |
TRIM29/1042
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Isotype |
Mouse / IgG2b, kappa
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Symbol |
ATDC
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GeneID |
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UniProt ID |
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Function |
It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.
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Summary |
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF, FC
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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