> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CDKN1A Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM02434G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDKN1A Antibody (C-term).
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Molecular Weight |
18119 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus.
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
117-146 aa
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Target |
This CDKN1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 117-146 amino acids from the C-terminal region of human CDKN1A.
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Clone |
592CT11.4.4
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Isotype |
IgG1
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Symbol |
CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA
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GeneID |
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UniProt ID |
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Function |
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Summary |
This gene encodes a potent cyclin-dependent kinaseinhibitor. The encoded protein binds to and inhibits the activityof cyclin-CDK2 or -CDK4 complexes, and thus functions as aregulator of cell cycle progression at G1. The expression of thisgene is tightly controlled by the tumor suppressor protein p53,through which this protein mediates the p53-dependent cell cycle G1phase arrest in response to a variety of stress stimuli. Thisprotein can interact with proliferating cell nuclear antigen(PCNA), a DNA polymerase accessory factor, and plays a regulatoryrole in S phase DNA replication and DNA damage repair. This proteinwas reported to be specifically cleaved by CASP3-like caspases,which thus leads to a dramatic activation of CDK2, and may beinstrumental in the execution of apoptosis following caspaseactivation. Multiple alternatively spliced variants have been foundfor this gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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