> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > SERPINC1 AntibodyBrand |
Leading Biology | Catalog Number |
AMM02410G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SERPINC1 Antibody.
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Molecular Weight |
52602 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted, extracellular space.
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Host |
Mouse
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Species Reactivity |
Human, Rat
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Immunogen |
364-393 aa
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Target |
This SERPINC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human SERPINC1.
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Clone |
435CT4.7.4
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Isotype |
IgG1
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Symbol |
AT3
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GeneID |
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UniProt ID |
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Function |
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
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Summary |
The protein encoded by this gene is a plasma proteaseinhibitor and a member of the serpin superfamily. This proteininhibits thrombin as well as other activated serine proteases ofthe coagulation system, and it regulates the blood coagulationcascade. The protein includes two functional domains: the heparinbinding-domain at the N-terminus of the mature protein, and thereactive site domain at the C-terminus. The inhibitory activity isenhanced by the presence of heparin. More than 120 mutations havebeen identified for this gene, many of which are known to causeantithrombin-III deficiency.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~500
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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