> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD79A Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM02373G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD79A Antibody (C-term).
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Molecular Weight |
25038 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
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Host |
Mouse
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Species Reactivity |
Mouse
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Immunogen |
160-188 aa
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Target |
This CD79A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human CD79A.
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Clone |
299CT22.1.2
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Isotype |
IgG1,k
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Symbol |
IGA, MB1
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GeneID |
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UniProt ID |
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Function |
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
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Summary |
The B lymphocyte antigen receptor is a multimeric complexthat includes the antigen-specific component, surfaceimmunoglobulin (Ig). Surface Ig non-covalently associates with twoother proteins, Ig-alpha and Ig-beta, which are necessary forexpression and function of the B-cell antigen receptor. This geneencodes the Ig-alpha protein of the B-cell antigen component.Alternatively spliced transcript variants encoding differentisoforms have been described.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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