> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > S100B AntibodyBrand |
Leading Biology | Catalog Number |
AMM02369G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality S100B Antibody.
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Molecular Weight |
10713 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus
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Host |
Mouse
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Species Reactivity |
Mouse
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Target |
This S100B monoclonal antibody is generated from mouse immunized with S100B recombinant protein.
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Clone |
271CT14.3.3
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Isotype |
IgM,k
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GeneID |
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UniProt ID |
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Function |
Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
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Summary |
The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21; however, this gene islocated at 21q22.3. This protein may function in Neurite extension,proliferation of melanoma cells, stimulation of Ca2+ fluxes,inhibition of PKC-mediated phosphorylation, astrocytosis and axonalproliferation, and inhibition of microtubule assembly. Chromosomalrearrangements and altered expression of this gene have beenimplicated in several neurological, neoplastic, and other types ofdiseases, including Alzheimer's disease, Down's syndrome, epilepsy,amyotrophic lateral sclerosis, melanoma, and type I diabetes.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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