> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > C-rel Antibody (ascites)Brand |
Leading Biology | Catalog Number |
AMM02365G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality C-rel Antibody (ascites).
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Molecular Weight |
68520 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus.
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Host |
Mouse
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Species Reactivity |
Human
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Target |
This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
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Clone |
318CT41.3.2
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Isotype |
IgG2b
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GeneID |
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UniProt ID |
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Function |
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
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Summary |
The REL gene encodes c-Rel, a transcription factor that isa member of the Rel/NFKB family, which also includes RELA (MIM164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012).These proteins are related through a highly conserved N-terminalregion termed the 'Rel domain,' which is responsible for DNAbinding, dimerization, nuclear localization, and binding to theNFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed18037997]).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF, E
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Dilution |
WB~~1:500~16000
IF~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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