> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CAMKK2 AntibodyBrand |
Leading Biology | Catalog Number |
AMM02357G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CAMKK2 Antibody.
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Molecular Weight |
64746 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.
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Host |
Mouse
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Species Reactivity |
Human, Mouse
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Target |
This CAMKK2 monoclonal antibody is generated from mouse immunized with CAMKK2 recombinant protein.
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Clone |
239CT7.5.3
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Isotype |
IgM,k
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Symbol |
CAMKKB, KIAA0787
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GeneID |
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UniProt ID |
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Function |
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
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Summary |
The product of this gene belongs to the Serine/Threonineprotein kinase family, and to the Ca(2+)/calmodulin-dependentprotein kinase subfamily. This protein plays a role in thecalcium/calmodulin-dependent (CaM) kinase cascade byphosphorylating the downstream kinases CaMK1 and CaMK4. Seventranscript variants encoding six distinct isoforms have beenidentified for this gene. Additional splice variants have beendescribed but their full-length nature has not been determined. Theidentified isoforms exhibit a distinct ability to undergoautophosphorylation and to phosphorylate the downstream kinases.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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