> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > HSPA1A AntibodyBrand |
Leading Biology | Catalog Number |
AMM02347G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HSPA1A Antibody.
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Molecular Weight |
70052 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
574-600 aa
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Target |
This HSPA1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 574-600 amino acids from human HSPA1A.
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Clone |
201CT8.2.3
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Isotype |
IgG1,K
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Symbol |
HSPA1, HSX70
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GeneID |
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UniProt ID |
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Function |
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
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Summary |
This intronless gene encodes a 70kDa heat shock proteinwhich is a member of the heat shock protein 70 family. Inconjuction with other heat shock proteins, this protein stabilizesexisting proteins against aggregation and mediates the folding ofnewly translated proteins in the cytosol and in organelles. It isalso involved in the ubiquitin-proteasome pathway throughinteraction with the AU-rich element RNA-binding protein 1. Thegene is located in the major histocompatibility complex class IIIregion, in a cluster with two closely related genes which encodesimilar proteins.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF, E
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Dilution |
WB~~1:100~2000
IF~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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