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SUMO3 Antibody

Catalog # Availability Size / Price Inquiry
AMM02328G 100 μl / $495

SUMO3 Antibody

Brand

Leading Biology

Catalog Number

AMM02328G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SUMO3 Antibody.

Molecular Weight

11637 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus. Nucleus, PML body

Host

Mouse

Species Reactivity

Human

Target

Purified recombinant GST-SUMO3 fusion protein was used as immunogen.

Clone

76AT630.91.31

Isotype

Mouse IgG1

GeneID

UniProt ID

Function

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.

Summary

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:100~500

Images

Western blot analysis of anti- SUMO3 Monoclonal Antibody in HL-60 cell line lysates (37ug/lane). SUMO3 was detected using the purified Mab.

Specification

Quantity

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