> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > GITR / Tnfrsf18 (mouse) Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMRa00007G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GITR / Tnfrsf18 (mouse) Antibody - With BSA and Azide.
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Molecular Weight |
66-70kDa (Homodimer)
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Cellular Localization |
Antigen Cellular Localization:
Isoform A: Cell membrane; Single-pass type I membrane protein Isoform C: Cell membrane; Single-pass type I membrane protein
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Host |
Rat
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Species Reactivity |
Mouse
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Clone |
DTA-1
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Isotype |
Rat / IgG2b, lambda
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Symbol |
Gitr
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GeneID |
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UniProt ID |
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Function |
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
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Summary |
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+?CD4+?Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-??B activation, and abrogate the inhibitory function of?CD25+?CD4+?Tregs. In vivo?activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IF, FC
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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