> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMM01404G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - With BSA and Azide.
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Molecular Weight |
250kDa
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules
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Host |
Mouse
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Species Reactivity |
Human
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Clone |
IIIE2.34
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Isotype |
Mouse / IgG1, kappa
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Symbol |
F8VWF
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GeneID |
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UniProt ID |
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Function |
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
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Summary |
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposiā€?s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF, FC, IP
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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