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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Cytokeratin 8 (KRT8) Antibody - With BSA and Azide

Cytokeratin 8 (KRT8) Antibody - With BSA and Azide

Catalog # Availability Size / Price Inquiry
AMM00139G 50 ug / $395

Cytokeratin 8 (KRT8) Antibody - With BSA and Azide

Brand

Leading Biology

Catalog Number

AMM00139G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cytokeratin 8 (KRT8) Antibody - With BSA and Azide.

Molecular Weight

52.5kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus, nucleoplasm Nucleus matrix

Host

Mouse

Species Reactivity

Human

Target

Keratin preparation from a human carcinoma

Clone

K8.8

Isotype

IgG1

Symbol

CYK8

GeneID

UniProt ID

Function

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Summary

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (“ring-like, perinuclear”) from ductal (“peripheral-predominant”) carcinoma of the breast.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, FC, IP, E

Images

Formalin-fixed, paraffin-embedded human colon carcinoma stained with Cytokeratin 8 MAb (K8.8).

Specification

Quantity

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