> Information Center > Technical FAQs > Antibody Technology Column > What is antibody affinity maturation?
Affinity maturation is the process by which Tfh cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. To be more specific, because antibodies can potentially be generated against millions of unique epitopes, the size of an organism’s genome would need to increase exponentially in order to code for every possible antigen-binding site. As a result, B-cells use a unique process called somatic hypermutation where the genes responsible for coding the antigen-binding site mutate rapidly in response to the antigen.
As successive generations of B cells mutate and are presented to the antigen, only those that recognize the antigen with high affinity will survive while B cells producing antibodies with low affinity will be eliminated. This process is known as affinity maturation.
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