Cell-free protein expression (also known as in vitro translation, In vitro protein expression, cell-free translation, or cell-free protein synthesis) as the name suggests is the production of recombinant proteins in cell lysates rather than within cultured cells. Cell free protein expression uses the biomolecular machinery with all the components extracted from the desired cell type. Cell free protein production can be done using various kinds and species of cell lysates, and these methods have numerous benefits and features over traditional in vivo methods. The global cell free protein expression market has been segmented on the basis of product type, application, expression mode, end users, and regions.

The global cell free protein expression market is projected to expand at a CAGR of 6.0% during the forecast period in terms of value. Global cell free protein expression market value is expected to increase to US$ 268.4 million by the end of 2024.

Factors influencing the global cell free protein expression market growth

Growth of the global cell free protein expression market is mainly driven by increasing R&D outsourcing by pharmaceutical and biotechnological companies, declining R&D productivity and patent cliff sales drop leading to increasing research intensity in the pharmaceutical sector and increasing expenditure on biosimilar development. Other factors driving cell free protein expression market are new and advanced applications, growing demand for simple and efficient protein production methods and rapid process/product development due to fewer steps.

However, low protein production, high cost and short reaction scale, lack of eukaryotic co- and post-translational modifications and inability to carry out humanized glycosylation patterns, are expected to restrain growth of the market over the forecast period. Focus on novel approaches and development of fast, reliable and cost-effective methods for industrial scale production of proteins from cell lysates will define the future landscape of cell free protein expression market.

Global cell free protein expression market forecast by product type

Based on product type, the market has been segmented into E. coli cell-free protein expression system, rabbit reticulocytes cell-free protein expression system, wheat germ cell-free protein expression system, insect cells cell-free protein expression system, mammalian cell-free protein expression system, and consumables. Mammalian cell-free protein expression system segment is expected to be the most lucrative segment in the cell free protein expression market owing to increasing applications of mammalian cell lysate in human antibody development studies.

Global cell free protein expression market forecast by application

Based on the major applications, the market has been segmented into enzyme engineering, protein labelling, protein-protein interaction, and protein purification. Protein-protein interaction segment currently accounts for the highest revenue of the cell free protein expression market owing to the robust research and development initiatives related to protein libraries generation.

Global cell free protein expression market forecast by expression mode

Based on expression mode, the cell free protein expression market is segmented into continuous flow expression and batch expression system. Continuous flow expression system is expected to account for the higher share for cell free protein expression market over the forecast period.

Global cell free protein expression market forecast by end user

Based on major end users, the cell free protein expression market is segmented into biotechnological companies, pharmaceutical companies, contract research organizations, and academic/research institutes. Academic/research institutes followed by contract research organizations are expected to account for the highest share for cell free protein expression market over the forecast period. Increasing outsourcing by pharmaceutical and biotechnological companies is expected to drive the cell free protein expression market in contract research organizations.

Global cell free protein expression market forecast by region

The global cell free protein expression market has been segmented into five major regions: North America, Latin America, Europe, Asia Pacific (APAC), and Middle East & Africa (MEA). In terms of value, North America is estimated to be the dominant market for global cell free protein expression market in 2016 owing to robust research and development infrastructure. The Europe cell free protein expression market is expected to register a CAGR of 5.9% over the forecast period. Asia Pacific is estimated to be the fastest growing market in terms of CAGR. North America cell free protein expression market is expected to register a CAGR of 5.8% over the forecast period.