Why do we need monoclonal antibodies?_Antibody Technology Column_Technical FAQs_Information Center

Monoclonal antibodies target various proteins that influence cell activity such as receptors or other proteins present on the surface of normal and cancer cells.The specificity of Monoclonal Antibodies allows its binding to cancerous cells by coupling a cytotoxic agent such as a strong radioactive which then seek outs to destroy the cancer cells while not harming the healthy ones.

Fusion of cell culture myeloma cells with mammalian spleen cells antibodies result in hybrid cells/hybridomas which produces large amounts of monoclonal antibody. The cell fusion resulted in two different types of cells, one with the ability to grow continually, and the other with ability to produce bulk amounts of purified antibody. Hybrid cells produce only 1 exact antibody that is more pure than polyclonal antibodies produced by conventional techniques. Monoclonal Antibodies are far more effective than conventional drugs since drugs attack the foreign substance & the body's own cells that cause harsh side effects & the monoclonal antibody only targets the foreign antigen/target molecule, without or only minor side effects.

The presence of a large amount of a specific monoclonal antibody in the blood means that there is an abnormal protein. Typically this protein can be detected during a physical examination and is identified using a screening blood test called “protein electrophoresis. The source of abnormal production of monoclonal antibody is a small population of plasma cells in the bone marrow.

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Why do we need monoclonal antibodies?

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