> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD44 / HCAM Std. Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMM00035G-T |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD44 / HCAM Std. Antibody - With BSA and Azide.
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Molecular Weight |
80-95kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Stimulated human leukocytes
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Clone |
156-3C11
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Isotype |
IgG2a, kappa
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Symbol |
LHR, MDU2, MDU3, MIC4
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GeneID |
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UniProt ID |
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Function |
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
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Summary |
Recognizes a cell surface glycoprotein of 80-95kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.
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Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF, FC, IP, E
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Product Description |
MIC Test Strips are a quantitative assay for determining the Minimum Inhibitory Concentration (MIC) of antimicrobial agents against microorganisms to indicate appropriate patient treatment and for identifying resistance patterns.
Ready to use. No preparation or dilution of antimicrobial agent is required. Simply place on an inoculated agar plate and incubate
MIC testing for a wide range of agents and against many organisms can be done on request and at short notice
Synergy Testing: can be crossed for evaluating a critical assay such as the in vitro combination of antibiotics
Rapid and Efficient: easy to set up. Full range of MIC testing of 6 agents on a large plate takes no more than 5 minutes
Solid Medium: Growth of organisms on agar better mimics in vitro conditions. It is easy to visualize hetero-resistant variants in a population and to detect mixed cultures and contamination
Inoculum Tolerant, Macro.Method: a stable gradient technique that is inoculum tolerant (changes in inoculum do not affect the MIC results for a susceptible strain), thus it can be used in a macro-format with heavier inoculum and a richer media to maximize the detection of low-level and hetero-resistance
Easy to Handle: The package is small and light weigh. Required storage space is minimal
Wide MIC Range: spans across 15 dilutions fulfilling pharmacokinetic needs, varying susceptibility of many organism groups, and covers different MIC breakpoints used in different countries as recommended by various reference or expert groups
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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