> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD46 (Membrane Cofactor Protein) Antibody - With BSA and AzideBrand |
Leading Biology | Catalog Number |
AMM00034G-T |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD46 (Membrane Cofactor Protein) Antibody - With BSA and Azide.
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Molecular Weight |
56-66kDa
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide
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Host |
Mouse
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Species Reactivity |
Human
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Target |
Recombinant human CD46 protein
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Clone |
122.2
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Isotype |
IgG1, kappa
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Symbol |
MCP, MIC10
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GeneID |
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UniProt ID |
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Function |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
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Summary |
CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
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Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, FC, IP, E
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Product Description |
MIC Test Strips are a quantitative assay for determining the Minimum Inhibitory Concentration (MIC) of antimicrobial agents against microorganisms to indicate appropriate patient treatment and for identifying resistance patterns.
Ready to use. No preparation or dilution of antimicrobial agent is required. Simply place on an inoculated agar plate and incubate
MIC testing for a wide range of agents and against many organisms can be done on request and at short notice
Synergy Testing: can be crossed for evaluating a critical assay such as the in vitro combination of antibiotics
Rapid and Efficient: easy to set up. Full range of MIC testing of 6 agents on a large plate takes no more than 5 minutes
Solid Medium: Growth of organisms on agar better mimics in vitro conditions. It is easy to visualize hetero-resistant variants in a population and to detect mixed cultures and contamination
Inoculum Tolerant, Macro.Method: a stable gradient technique that is inoculum tolerant (changes in inoculum do not affect the MIC results for a susceptible strain), thus it can be used in a macro-format with heavier inoculum and a richer media to maximize the detection of low-level and hetero-resistance
Easy to Handle: The package is small and light weigh. Required storage space is minimal
Wide MIC Range: spans across 15 dilutions fulfilling pharmacokinetic needs, varying susceptibility of many organism groups, and covers different MIC breakpoints used in different countries as recommended by various reference or expert groups
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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