> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Rat IL-1βBrand |
Leading Biology | Catalog Number |
PR0011E2 |
Product Type |
Cytokine | Field of Research |
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Product Overview |
IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities, including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and, the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Rat IL-1β is a 17.4 kDa protein containing 153 amino acid residues.
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Mouse
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AA Sequence |
MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS
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Tags |
Tag-Free
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Molecular Weight |
17.4 kDa
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Activity |
The ED50 was determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
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Form |
Lyophilized |
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Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Interleukin-1 beta known as catabherin, is a member of the interleukin-1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth and tissue repair of the cortex.
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Synonyms |
Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
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Images |
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Quantity |
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