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FGFR2 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR24599N-1 50ul / $395
APR24599N-2 100ul / $495
APR24599N-3 200ul / $595

FGFR2 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR24599N

Product Type

Polyclonal Antibodies

Field of Research

Cardiovascular>Angiogenesis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGFR2 Polyclonal Antibody.

Molecular Weight

Calculated MW: 28kDa/40kDa/76-92kDa Observed MW: 110kDa

Species Reactivity

Rabbit

Immunogen

A synthetic peptide of human FGFR2 (NP_000132.3).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Product Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Synonyms

FGFR2; BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; fibroblast growth factor receptor 2

Images

Western blot analysis of extracts of various cell lines, using FGFR2 antibody.

Immunohistochemistry of paraffin-embedded rat spleen using FGFR2 antibody.

Immunohistochemistry of paraffin-embedded human placenta using FGFR2 antibody.

Specification

Quantity

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