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GBP5 Antibody

Catalog # Availability Size / Price Inquiry
APR06819G 0.1 mg / $695

GBP5 Antibody

Brand

Leading Biology

Catalog Number

APR06819G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GBP5 Antibody.

Molecular Weight

Predicted: 64 kDa Observed: 66 kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Membrane; Lipid-anchor.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

GBP5; GBP5 antibody is predicted to not cross-react with other GBP family members.

Isotype

IgG

GeneID

UniProt ID

Function

Stimulates the NLRP3 inflammasome assembly upon bacterial challenge.

Summary

GBP5 Antibody: The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of GBP5 in rat liver tissue lysate with GBP5 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of GBP5 in human liver tissue with GBP5 antibody at 2.5 μg/ml.

Immunofluorescence of GBP5 in human liver tissue with GBP5 antibody at 20 μg/ml.

Specification

Quantity

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