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Location: Home > Antigens, Antibodies, ELISA, Western Blo > Primary Antibody > Anti-alpha-Synuclein Polyclonal Antibody

Anti-alpha-Synuclein Polyclonal Antibody

AH0002R1
Catalog # Availability Size / Price Inquiry
AH0002R1-50uL  In Stock 50μL / $195
AH0002R1-200uL  In Stock 200μL / $345

Anti-alpha-Synuclein Polyclonal Antibody

Brand

Leading Biology

Catalog Number

AH0002R1

Product Type

Primary Antibody

Field of Research

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human alpha-Synuclein protein

Isotype

IgG

Form

Liquid

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Applications

WB, ELISA, IHC, IC/IF, IP, FC

Product Description

Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement. It has been shown that alpha-synuclein significantly interacts with tubulin, and that alpha-synuclein may have activity as a potential microtubule-associated protein, like tau. Recent evidence suggests that alpha-synuclein functions as a molecular chaperone in the formation of SNARE complexes. In particular, it simultaneously binds to phospholipids of the plasma membrane via its N-terminus domain and to synaptobrevin-2 via its C-terminus domain, with increased importance during synaptic activity. Indeed, there is growing evidence that alpha-synuclein is involved in the functioning of the neuronal Golgi apparatus and vesicle trafficking. Apparently, alpha-synuclein is essential for normal development of the cognitive functions. Knock-out mice with the targeted inactivation of the expression of alpha-synuclein show impaired spatial learning and working memory.

Synonyms

Anti-NACP Antibody; Anti-SNCA Antibody

Images

Quantity

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