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PRKAB1 Antibody (monoclonal) (M01)Brand |
Leading Biology | Catalog Number |
AMR09532G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PRKAB1 antibody (monoclonal) (M01).
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Molecular Weight |
30382 Da
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Host |
mouse
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Species Reactivity |
Human
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Target |
PRKAB1 (AAH01007, 1 a.a. ~ 270 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Clone |
3H12-1A10
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Isotype |
IgG1 kappa
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GeneID |
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UniProt ID |
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Summary |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
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Form |
Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:500~1000
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Synonyms |
5'-AMP-activated protein kinase subunit beta-1, AMPK subunit beta-1, AMPKb, PRKAB1, AMPK
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Images |
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (55.44 KDa) . Western Blot analysis of PRKAB1 expression in transfected 293T cell line by PRKAB1 monoclonal antibody (M01), clone 3H12-1A10. Lane 1: PRKAB1 transfected lysate(31.05 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged PRKAB1 is approximately 1ng/ml as a capture antibody. |
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Specification |
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Quantity |
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