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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PTPN6 / SHP1 Antibody (clone 14D5)

PTPN6 / SHP1 Antibody (clone 14D5)

Catalog # Availability Size / Price Inquiry
AMM02105G 50 μl / $495

PTPN6 / SHP1 Antibody (clone 14D5)

Brand

Leading Biology

Catalog Number

AMM02105G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PTPN6 / SHP1 Antibody (clone 14D5).

Molecular Weight

68kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.

Host

Mouse

Species Reactivity

Human

Clone

14D5

Symbol

HCP, PTP1C

GeneID

UniProt ID

Function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Summary

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

IHC-P (1:200), WB (1:2000),

Images

Anti-PTPN6 antibody IHC of human tonsil.

Specification

Quantity

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