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Recombinant Mouse CCL3 ProteinBrand |
Leading Biology | Catalog Number |
PM0058E2 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Mouse
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AA Sequence |
P10855(Ala24-Ala92)
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Tags |
Tag-Free
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Molecular Weight |
12KD
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Activity |
Measured by its ability to chemoattract 2-day cultured human monocytes.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered 30% acetonitrile 0.1%TFA
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Product Description |
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes.through binding to the receptors CCR1, CCR4 and CCR5.CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.
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Synonyms |
AI323804 Protein(Mouse); G0S19-1 Protein(Mouse); LD78 alpha Protein(Mouse); MIP-1 alpha Protein(Mouse)
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Images |
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Quantity |
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|
$325.00 | Add Ask |
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